ABOUT

SLE (Systemic Lupus Erythematosus) -
Lupus Centre of Excellence

AstraZeneca / SLE Awareness Pitch Concepts.
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Main Concept:
PEAK. (Pursuing Excellence And Knowledge sharing in SLE)
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Alternative Concepts:
RISE. (Revolutionise Care in SLE)
STEP. (Into A Brighter Future in SLE
SHIFT. ( Into a Brighter Future in SLE)
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Background:

SLE is a chronic disease in which the body’s immune system attacks healthy tissue in any part of the body. It’s experienced differently by each person and can cause a wide range of debilitating symptoms, including skin rash, joint pain, swelling and fevers. There have been very few new medicines for SLE, and the significant physical, emotional and socio-economic burden remains high for people living with the disease.

Scientists at AstraZeneca are building on existing disease knowledge and emerging biology, applying learnings from other therapeutic areas, such as cancer, to advance new treatment approaches for SLE. These efforts are critical for those people with SLE who continue to experience inadequate disease control with current therapies. Advanced modalities, such as novel antibody approaches and cell therapies, are being explored to help control the underlying processes that cause SLE with the goal of achieving lasting disease remission.

Treatment Goals:

The recently updated international SLE treatment recommendations from the European Alliance of Associations for Rheumatology (EULAR) emphasise the need for prompt initiation of treatment aiming at remission, which is associated with improved clinical outcomes including reduced organ damage, fewer flares, reduced hospitalisation, reduced mortality and improved health-related quality of life. The revised SLE treatment recommendations advise an OCS-sparing approach (a threshold of 5mg per day or less) to significantly reduce disease progression and improve quality of life for patients.

Mission Statement:

Our ambition is to bring forth new transformational therapies for multiple immune-mediated diseases. We aim to move beyond symptom control to drive clinical remission and, eventually, cure in immune-mediated diseases with high unmet need, such as systemic lupus erythematosus (SLE).
We intend to show the world what science can do... as we strive to transform outcomes for those living with immune-mediated diseases.